5th Annual WSU Celebration of Research and Creative Scholarship
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Poster #83 - The Effect of Metformin on Glycolysis of Yeast Cells Thanh M. Nguyen Faculty Co-author: Myoung E. Lee Diabetes mellitus is a metabolic disease with escalating occurrence worldwide. In 2007, an estimate of 23.6 million people in the United States or 7.8% population was considered to have diabetes. Metformin, a biguanide (dimethyl biguanide) anti-hyperglycemic agent is one of the most popular drugs used for type 2 diabetes treatment. However, the mechanism of metformin or how it works to treat diabetes in the body is still left unclear. In order to figure out the mechanism of metformin, the effect of metformin on glycolysis of yeast cells was researched. Glycolysis of yeast cells was analyzed by C-13 NMR. NMR signals as a function of time of two reactants and two products were analyzed. It can be seen that glycolysis of yeast cells with metformin did not have much change compared to glycolysis of yeast cells without metformin. This indicates that metformin has no effect on glycolysis of yeast cells. |
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